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Infected surgical equipment may have spread brain disease to 13 patients

MANCHESTER, NH - Public health officials believe one person in New Hampshire died of a rare, degenerative brain disease, and say there's a remote chance up to 13 others in multiple states were exposed to the fatal illness through surgical equipment.

Dr. Joseph Pepe, president of Catholic Medical Center in Manchester, said officials are 95 percent certain that a patient who had brain surgery in May and died in August had sporadic Creutzfeldt-Jakob Disease.

The disease progresses rapidly once symptoms appear and is always fatal, usually within a few months. But the symptoms can take decades to show up. They include behavior changes, memory loss, impaired coordination and other neurological problems.

The abnormal proteins that cause the disease can survive standard sterilization practices putting those who have surgery after an infected patient at risk, Pepe said.

"The risk of exposure is extremely low, but it's not zero," he said.

Only four cases of transmission via surgical instruments have been recorded, none in the United States according to state public health director Dr. Jose Montero.

The disease can be verified only through a brain biopsy or autopsy. New Hampshire officials are still awaiting those results.

Meanwhile, the hospital has notified eight of its patients who may have been exposed, and hospitals in other states are working to do the same because some of the surgical equipment was rented and used elsewhere after being used in Manchester, Montero said. He would not identify the other states but said no more than five additional patients were potentially exposed.

Catholic Medical Center also has assigned a staffer to work with the potentially exposed patients, whom Pepe said range in age from mid-30s to mid-80s.

"They took it very well. I don't believe that people were angry or extremely emotionally upset," he said. "We did the best job we could in trying to alleviate their fear."

Worldwide, Creutzfeldt-Jakob affects about one person in every one million each year; in the United States, about 200 cases are recorded annually, according to the National Institutes of Health.

The New Hampshire equipment has been quarantined pending the autopsy results.

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