Bobby McCain and Dontrell Nelson each had interception returns for touchdowns to help Memphis beat Tulane 38-7 on Saturday.
Memphis (7-3, 5-1 American) forced a season-high five turnovers, ruining Tulane's first on-campus homecoming in more than four decades.
McCain intercepted Tanner Lee's first pass and returned it 15 yards for a touchdown and Memphis never looked back, taking a 31-0 into the fourth quarter.
Trailing 17-0 late in the third quarter, Lee hit Justyn Shackleford for a 19-yard gain, giving Tulane (3-7, 2-4) a first down near midfield. Two plays later, however, Nelson sealed Memphis' fourth consecutive win with a 58-yard interception return for a touchdown.
Paxton Lynch completed 14 of 25 passes for 178 yards and a score and added a 4-yard rushing touchdown in the win.
Lee was 26-of-48 passing for 196 yards with three interceptions.